Distinctive shift technology
HYDRASHIFT daratumumab and HYDRASHIFT isatuximab avoid daratumumab or isatuximab interference on HYDRAGEL IF tests.
HYDRASHIFT
Avoid interferences due to therapeutic Monoclonal Antibody with HYDRASHIFT Portfolio.
About HYDRASHIFT
Therapeutic monoclonal antibody (mAb) inclusion in Multiple Myeloma treatment regimens offer patients significant improvements in clinical outcomes. daratumumab and isatuximab are human mAb targeting CD38 used in Multiple Myeloma treatment regimens.
HYDRASHIFT avoids therapeutic mAb interference on Immunofixation interpretation assays.
Key benefits
HYDRASHIFT : A simple and reliable solution to eliminate interferences from therapeutic monoclonal antibodies.
Trust in the results
HYDRASHIFT reduce the risk of incorrect IF interpretation to improve therapy monitoring.
Easy to implement
Fully integrated into IF protocol without sample pre-treatment for a standardized process compliant to IMWG guidelines.
Follow IMWG guidelines
Process compliant to IMWG guidelines to assess response to treatment in patient with Multiple Myeloma.
Main characteristics
Test principle
HYDRASHIFT is an immunofixation technique performed on HYDRAGEL IF 2/4 gel that works by creating immune complexes between therapeutic monoclonal antibodies (daratumumab or isatuximab) and specific anti-mAB antisera. The resulting complexes shift migration to the alpha region, facilitating distinction from patient M-proteins.
This complex is visible in the IgG and kappa immunofixation tracks. A negative HYDRASHIFT result demonstrates the absence of endogenous M-protein.
Sample type
Serum
Performances
Sensitivity
The limit of immune complex visualized is 0.3 g/L.
Product details
- HYDRASHIFT 2/4 daratumumab (20 tests) – P/N: 4639
- daratumumab control – P/N: 4765
- HYDRASHIFT 2/4 isatuximab (40 tests) – P/N: 4642
- isatuximab control P/N: 4764
Knowledge & Science
M. Jean Deenmamode, IFCC CDT Working group Chair, during this interview comes back on the definition of the excessive chronic alcohol consumption and its impact on the individuals and society.
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Expanding offering for Multiple Myeloma and AL Amyloidosis Testing.
HYDRASHIFT test can be performed on the following instrument
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