Educational Webinar with Dr Nadia Maria Porpiglia
Chronic Alcohol Abuse
Reducing the Burden of Excessive Chronic Alcohol Consumption.
Excessive and long‑term alcohol consumption has serious consequences for both individuals and society. Beyond its well‑documented health risks, it generates a substantial economic burden. In 2016, alcohol use ranked as the seventh leading risk factor for death and disability worldwide, and it was the primary risk factor among people aged 15 to 49 years.
While global economic estimates are not yet available, the financial impact has been quantified in some countries. In the United States, for example, the cost of excessive chronic alcohol consumption reached $60 billion in 2010, driven by productivity losses, healthcare expenses, and other social impacts such as traffic-related incidents.
What is chronic alcohol abuse ?
Situations in which Alcohol Consumption must be avoided
Alcohol consumption should be strictly avoided in the following circumstances:
- During pregnancy
- During childhood and adolescence
- While driving or operating machinery
- When performing activities requiring attention and vigilance
- When taking medications that interact with alcohol
- In the presence of certain chronic or acute medical conditions (such as epilepsy, pancreatitis, viral hepatitis, etc.)
- By individuals with a history of alcohol dependence
Reducing harmful alcohol use is a public health priority. Meaningful progress requires sustained and coordinated efforts across industries, healthcare organizations, and individuals, each playing a part in minimizing the impact of excessive alcohol consumption.
Definition of Safe or Responsible Drinking
For women:
- No more than 2–3 units of alcohol per day on average (maximum 14 units per week)
- At least two alcohol‑free days per week
For men:
- No more than 3–4 units of alcohol per day on average (maximum 21 units per week)
- At least two alcohol‑free days per week
Occasional consumption:
- Should not exceed 4 units of alcohol on a single occasion.
Alcohol abuse is still one of the leading causes of death worldwide. Early diagnosis of alcohol abuse enables preventive intervention on the effects and risks associated with its consumption.
200
diseases and injuries conditions are caused by alcohol consumption
2.6
million deaths were caused by alcohol consumption in 2019
400
million persons worldwide, aged 15 years and older, lived with alcohol use disorders
How do we diagnose Chronic Alcohol Abuse?
Cost‑Effective Policies and the Role of CDT in Detecting Chronic Alcohol Use
Implementing cost‑effective policies for the detection, diagnosis, and monitoring of alcohol misuse in clinical, industrial, and forensic settings can significantly improve clinical outcomes, reduce drink‑driving incidents, diminish workplace accidents, and ultimately lower the economic burden associated with alcohol‑related harm.
Carbohydrate‑Deficient Transferrin (CDT) is recognized for its reliability as blood biomarker for chronic excessive alcohol consumption. Daily alcohol intake exceeding approximately 60 g per day over a period of about two weeks leads to an increase in CDT levels, reflecting alcohol‑induced disruption of normal liver cell function. In most individuals, elevated CDT values return to normal after several weeks of abstinence.
CDT is highly specific for heavy drinking, and a 30% reduction in CDT indicates a meaningful decrease in alcohol intake. In many respects, CDT behaves similarly to HbA1c and other biochemical markers that vary according to lifestyle or therapeutic interventions. A rising CDT level serves as an objective indicator of relapse into heavy alcohol use, making it a sensitive and specific monitoring tool for healthcare professionals.
CDT is the recommended marker for chronic alcohol use assessment by the IFCC.
Knowledge & Science
Educational Webinar with M. Jean Deenmamode, IFCC Working Group Chair
Understand in 2 minutes how capillary electrophoresis works, and why it gives such high and clear resolution in lab testing.
Instruments for diagnosing Chronic Alcohol Abuse
The compact and affordable automation of Capillary Electrophoresis.
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Capillary Electrophoresis solution to meet your high capacity needs.